Kiss-and-run, Collapse and ‘Readily Retrievable’ Vesicles
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چکیده
منابع مشابه
Kiss-and-run, collapse and 'readily retrievable' vesicles.
Two models of synaptic vesicle recycling have been intensely debated for decades: kiss-and-run, in which the vesicle opens and closes transiently, presumably through a small fusion pore, and full fusion, in which the vesicle collapses into the plasma membrane and is retrieved by clathrin-coat-dependent processes. Conceptually, it seems that kiss-and-run would be faster and would retrieve vesicl...
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New measurements show that the entire transmitter contents of a dense-core vesicle can be released within a second through a narrow fusion pore that opens transiently. With other results, this raises the possibility that some dense core vesicles may, like small synaptic vesicles, undergo immediate recycling.
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We have combined electrophysiology and imaging to measure the release of neurotransmitter and fluorescent dye at synapses of cultured hippocampal neurons. These experiments have revealed a "kiss and run" mode of exocytosis in which synaptic vesicles release glutamate normally but do not permit dye to enter or escape from the vesicle. During "kiss and run," the vesicle interior may be exposed ve...
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Recent results have provided graphic support for the hypothesis that vesicle secretion involves a 'kiss-and-run' mechanism. Evanescent field microscopy has shown that, during exocytosis, intravesicular markers escape without collapse of the vesicular membrane into the surface membrane and that the empty vesicle is immediately retrieved back into the cell.
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T he fate of secretory membrane after fusion with the cell surface has been a subject of interest and considerable debate for almost 30 years. At nerve terminals, the limited number of synaptic vesicles and often high rates of action potential firing require that efficient machinery be in place to recover and replenish the vesicle pool to sustain the f low of information across the synapse over...
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ژورنال
عنوان ژورنال: Traffic
سال: 2007
ISSN: 1398-9219
DOI: 10.1111/j.1600-0854.2007.00614.x